Design, scale-up, cost evaluation of recombinant protein production process
Animal cell culture processes
ONLINE COURSE: On-demand
COURSE FEE: 300 € per session
COURSE ORGANIZATION
Course organized in 3 sessions
Scheduling: suggested one session per week
Effort: 4 - 8 hours per session
COURSE DESCRIPTION
The course teaches the methodology for the design and cost evaluation of a monoclonal antibody production process by recombinant CHO cells. It involves the evaluation of the production and purification process material balance,equipment sizing, energy consumption, investment cost and antibody production cost.
INSTRUCTOR
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Jean-Marc ENGASSER, BioProcess Digital
DIGITAL LEARNING
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Learning platform with course resources
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Live or recorded slideshow videos
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Process design and cost evaluation on spreadsheet templates with self-corrections and guides
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Online collective or one-to-one tutoring
COURSE PROGRAM
SESSION 1: PROCESS MATERIAL BALANCE
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Flowsheet of the mAbs production and purification process
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Materials consumption of the upstream and downstream process sections
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Antibodies and effluents productions
SESSION 2: PROCESS EQUIPMENT SIZING AND ENERGY CONSUMPTION
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Sizes of the bioreactor, membrane and chromatography equipment
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Mechanical and thermal energy consumption
SESSION 3: INVESTMENT AND PRODUCTION COST
Investment cost for the production plant
Materials, energy, equipement utilization and labor costs
Sensitivity and uncertainty analysis of the mAbs production cost