Introduction to microbial fermentations engineering
Industrial fermentations kinetics, simulation, and digital optimization
ONLINE COURSE: On-demand
COURSE FEE: 350 € per session
COURSE ORGANIZATION
Course organized in 3 sessions
Scheduling: suggested one session per week
Effort: 3 - 6 hours per session
COURSE DESCRIPTION
This introductory course offers a foundational understanding of microbial fermentation engineering, tailored for students and professionals entering the field of bioprocess engineering. It explore the essential principles used to simulate, scale-up, ,and optimize microbial fermentation processes across various applications.
Methodologies of kinetic analysis, process simulation and digital optimization are outlined on examples of aerobic and anaerobic fermentations for the production of cells, metabolites and proteins.
INSTRUCTOR
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Jean-Marc Engasser, BioProcess Digital
DIGITAL LEARNING
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Learning platform with course resources
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Live or recorded slideshow presentations
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Case studies on spreadsheet templates
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Online collective or one-to-one tutoring
COURSE PROGRAM
SESSION 1: MICROBIAL FERMENTATIONS KINETICS
Review of industrial fermentation kinetics: aerobic and anaerobic fermentations for the production of cells, metabolites and proteins
Experimental kinetic analysis for the evaluation of fermentation rates and microbial specific rates of cells growth, substartes consumption, metabolites production
SESSION 2: MICROBIAL FERMENTATIONS SIMULATION
Knowledge simulation models, based on fermentations influencing phenomena of cellular reaction, oxygen and carbon dioxide solubilization and transfer
Fermentations simulation relations: cellular rates laws, oxygen and carbon dioxide solubility and transfer laws, components mass balances
SESSION 3: MICROBIAL FERMENTATIONS OPTIMIZATION
Simulation-based digital optimization of microbial fermentors. Comparative kinetics in batch, continuous and fed-batch operation modes
Optimization of fermentation operational variables -substrates concentrations, medium flow rate, fermentation times- for maximum fermentor productivity. Maximal cell concentration by oxygen transfer.