Simulation, scale-up, optimization of soluble and immobilized enzymes bioreactors
Enzymatic bioconversion processes
ONLINE COURSE: On-demand
COURSE FEE: 300 € per session
COURSE ORGANIZATION
Course organized in 8 sessions
Scheduling: suggested one session per week
Effort: 4 - 8 hours per session
COURSE DESCRIPTION
The course teaches the methodology of the kinetic analysis, the modeling-simulation, the scale-up, and the optimization of soluble and immobilized enzymes bioreactors.
The guiding thread of the course is a virtual R&D project on starch bioconversion by a glucoamylase enzyme. The objective is to design the most cost-efficient industrial bioreactor to hydrolyze maltodexrins into glucose.
INSTRUCTOR
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Jean-Marc ENGASSER, BioProcess Digital
WHAT YOU'LL LEARN?
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Design and analyze experiments to determine the kinetics of enzymatic reactions
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Construct simulation models of soluble and immobilized enzymes reactors
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Use simulators to scale up and optimize batch and continuous enzyme bioreactors
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Evaluate the cost of enzymatic bioconversions
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Determine the bioreactors operational variables (temperature, enzyme concentration) to reach the lowest bioconversion cost
DIGITAL LEARNING
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Learning platform with course resources
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Live or recorded slideshow videos
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Bioconversion project on spreadsheets templates with self-corrections and guides
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Online collective or one-to-one tutoring
COURSE PROGRAM
SESSION 1: KINETIC ANALYSIS OF THE ENZYMATIC BIOCONVERSION
At the laboratory, kinetic analysis of the enzymatic reaction and denaturation. Influence of temperature
SESSION 2: MODELING-SIMULATION OF THE ENZYMATIC BIOCONVERSION
Modeling-simulation of the bioconversion in the batch reactor. Influence of temperature and enzyme concentration
SESSION 3: SCALE-UP AND OPTIMIZATION OF THE BIOCONVERSION IN A BATCH REACTOR
Scale-up of the simulation model. Cost evaluation of the bioconversion. Optimal operation of the batch reactor
SESSION 4: OPTIMIZATION OF THE BIOCONVERSION IN A CONTINUOUS STIRRED REACTOR
Simulation and optimal operation of the bioconversion in the continuous stirred reactor
SESSION 5: OPTIMIZATION OF THE BIOCONVERSION IN A CONTINUOUS TUBULAR REACTOR
Simulation and optimal operation of the bioconversion in the continuous tubular reactor
SESSION 6: OPTIMIZATION OF THE BIOCONVERSION IN A MEMBRANE BIOREACTOR
Simulation and optimal operation of the bioconversion in the continuous membrane reactor
SESSION 7: MODELING-SIMULATION OF THE IMMOBILIZED ENZYME KINETICS
Modeling-simulation of the bioconversion by immobilized enzymes. Influence of diffusional limitations
SESSION 8: SCALE-UP AND OPTIMIZATION OF THE BIOCONVERSION IN A FIXED-BED REACTOR
Simulation and optimal operation of the bioconversion in the immobilized enzymes fixed-bed reactor