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Introduction to bioprocess design, scale-up and simulation

Bioprocess engineering scope and methodology

ONLINE COURSE: On-demand

COURSE FEE: 300 € per session  

COURSE CONTENT

4 sessions

Scheduling: suggested one session per week

Effort: 3 to 6 hours per session

COURSE DESCRIPTION

This short course provides an introduction to the scope and methodology of bioprocess engineering. It outlines the design, scale-up, economic and environmental optimization, and modeling-simulation of industrial bioprocesses. The course offers a combination of methodological presentations and two case study projects.

INSTRUCTOR​

  • Jean-Marc Engasser, BioProcess Digital

WHO SHOULD ATTEND?

The course is aimed at biologists, chemists, engineers, technicians and managers in the chemical, pharmaceutical, food and environmental industries. It is particularly relevant to anyone involved in the development and scale-up of enzymatic, microbial or animal cells bioprocesses

WHAT YOU'LL LEARN?​

  • Industrial bioprocesses and applications 

  • Bioprocess unit operations

  • Challenges and methods of bioprocess design, scale-up, economic and environmental optimization

  • Tailored design of bioreactors 

  • Simulation models for the digital scale-up and optimization of bioprocesses

  • The three-stages bioprocess engineering methodology: scientific fundamentals, unit operations simulation, design and scale-up, integrated optimization

DIGITAL LEARNING

  • Learning platform with course resources

  • Live or recorded slideshow videos

  • Process design and cost evaluation on spreadsheet templates with self-corrections and guides

  • Online collective or one-to-one tutoring

COURSE PROGRAM

SESSION 1 

Bioprocess engineering

  • Industrial bioprocesses

  • Design and scale-up of bioprocesses

Case study: Enzyme production process design

Material balance

Energy consumption

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SESSION 2 

Bioprocess engineering

  • Bioprocesses economic and environmental optimization

Case study: Enzyme production process design 

Equipment sizing

Investment and production costs evaluation

Environmental impacts evaluation

SESSION 3 

Bioprocess engineering

  • Modeling-simulation of bioprocesses

Case study: Yeast fermentation optimization

Construction of simulation-models of batch and continuous fermentations

SESSION 4 

Bioprocess engineering​

  • Bioprocess engineering methodology

Case study: Yeast fermentation optimization

Digital scale-up and optimization of the yeast fed-batch fermentation

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Online courses
Introduction to bioprocess design, scale-up and simulation
Bioprocess engineering basic principles

Bioprocess design and cost evaluation

Introduction to bioprocess Life Cycle Assessment

Life Cycle Assessment of bioprocesses and byproducts

Introduction to microbial fermentation processes
Simulation, scale-up, and optimal operation of microbial fermentors

Animal cells bioreactors principles and optimal operations

Simulation, scale-up, and optimal operation of suspended and adherent animal cells bioreactors

Design, scale-up, and cost evaluation of recombinant proteins production
Introduction to enzymatic bioconversion processes
Simulation, scale-up, and optimization of soluble and immobilized enzyme bioreactors

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